ESCO: single cell expression simulation incorporating gene co-expression
نویسندگان
چکیده
منابع مشابه
Stochastic Simulation of Gene Expression in a Single Cell
In this paper, we onsider two sto hasti models of gene expression in prokaryoti ells. In the rst model, sixteen bio hemi al rea tions involved in trans ription, translation and trans riptional regulation in the presen e of indu er mole ules are onsidered. The time evolution of the number of biomole ules of a parti ular type is determined using the sto hasti simulation method based on the Gilles...
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MOTIVATION Stochastic promoter switching between transcriptionally active (ON) and inactive (OFF) states is a major source of noise in gene expression. It is often implicitly assumed that transitions between promoter states are memoryless, i.e. promoters spend an exponentially distributed time interval in each of the two states. However, increasing evidence suggests that promoter ON/OFF times c...
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Motivation: Stochastic promoter switching between transcriptionally active (ON) and inactive (OFF) states is a major source of noise in gene expression. It is often implicitly assumed that transitions between promoter states are memoryless, i.e. promoters spend an exponentially distributed time interval in each of the two states. However, increasing evidence suggests that promoter ON/OFF times ...
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A key goal of biology is to relate the expression of specific genes to a particular cellular phenotype. However, current assays for gene expression destroy the structural context. By combining advances in computational fluorescence microscopy with multiplex probe design, we devised technology in which the expression of many genes can be visualized simultaneously inside single cells with high sp...
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Cellular behavior has traditionally been investigated by utilizing bulk-scale methods that measure average values for a population of cells. Such population-wide studies mask the behavior of individual cells and are often insufficient for characterizing biological processes in which cellular heterogeneity plays a key role. A unifying theme of many recent studies has been a focus on the developm...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2021
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btab116